R&D

The current standard wound care consist of effective cleansing, local therapy with antimicrobials and wound cover, complemented if necessary with adequate compression therapy or pressure offloading.
Hard to heal wounds such as chronic venous leg ulcers, diabetic (foot) ulcers or pressure ulcers are long-lasting (hard to heal) wounds which are difficult to treat with high costs and labor intensive.
Unfortunately standard treatments are not always as effective and there is continuous research for improved methods. Two important factors with a major impact on the efficacy of cultured skin replacing products are: 1. the origin of the skin tissue (cells), 2. the composition of the cultured product.

Autologous or allogeneic

Skin cells used for culturing skin tissues can originate from two kinds of sources: from the patient’s own body (autologous) or from a donor (allogeneic). In general, autologous skin replacement products have the benefit that these will not be rejected by the patient’s body. These also provide immediate wound cover and stimulation of the wound bed, and stimulate the healing process maximally.

Structure of the skin tissue product

Skin tissue products may consist of one (single layered) or two (bi-layered) layers, also known as full-thickness skin) layers. Full-thickness skin contains two layers of skin, just like the natural human skin: the dermal and epidermal layer, connected by a basement membrane. The full thickness skin is stronger than a single-layered product and reduces the risk of recidivism. All currently available data indicates that the full-thickness skin product with an autologous origin, are the most optimal skin replacement product for the treatment of hard to heal skin wounds.

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